P-Selectin and Blood Coagulation

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Role of P-selectin and PSGL-1 in coagulation and thrombosis.

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Blood cell dynamics in P-selectin-deficient mice.

P-selectin is expressed on the surfaces of activated platelets and endothelium where it mediates binding to leukocytes. P-selectin-deficient mice were shown to exhibit peripheral neutrophilia (Mayadas et al: Cell 74:541, 1993). We now show that this is not caused by changes in bone marrow precursors nor by a lack of neutrophil margination. Both P-selectin-positive and -negative animals displaye...

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ژورنال

عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology

سال: 2005

ISSN: 1079-5642,1524-4636

DOI: 10.1161/01.atv.0000161049.53535.5d